Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 2
Ligand
BDBM309520
Substrate
n/a
Meas. Tech.
FLIPR Assay
IC50
185±n/a nM
Citation
 Yuan, H; Beard, RL; Garst, ME; Liu, X; Donello, JE; Viswanath, V 1,2- bis-sulfonamide derivatives as chemokine receptor modulators US Patent  US9603834 Publication Date 3/28/2017 
Target
Name:
C-C chemokine receptor type 2
Synonyms:
C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:
Enzyme
Mol. Mass.:
41932.32
Organism:
Homo sapiens (Human)
Description:
P41597
Residue:
374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
  
Inhibitor
Name:
BDBM309520
Synonyms:
N-{2-[(1-benzofuran-2-ylsulfonyl)amino]-4-chlorophenyl}-1-methyl-1H-pyrazole-3-sulfonamide | US9603834, 19
Type:
Small organic molecule
Emp. Form.:
C18H15ClN4O5S2
Mol. Mass.:
466.919
SMILES:
Cn1ccc(n1)S(=O)(=O)Nc1ccc(Cl)cc1NS(=O)(=O)c1cc2ccccc2o1
Structure:
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