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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1) | ||
| Ligand | BDBM50092330 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | FP Competitive Binding Assay (No.350) | ||
| Temperature | 298.15±n/a K | ||
| Ki | 305±26 nM | ||
| Comments | extracted | ||
| Citation |  Wang, S; Ran, X; Zhao, Y; Yang, C; Liu, L; Bai, L; McEachern, D; Stuckey, J; Meagher, JL; Sun, D; Li, X; Zhou, B; Karatas, H; Luo, R; Chinnaiyan, A; Asangani, IA BET bromodomain inhibitors and therapeutic methods using the same US Patent US9675697 Publication Date 6/13/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1) | |||
| Name: | Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1) | ||
| Synonyms: | Bromodomain-containing protein 4 (BD1) | Bromodomain-containing protein 4 Bromodomain 1 (BRD4-1) | Bromodomain-containing protein 4 Domain 1 | ||
| Type: | n/a | ||
| Mol. Mass.: | 8856.55 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | BD1 (75-147 aa) of O60885 | ||
| Residue: | 73 | ||
| Sequence: |
| ||
| BDBM50092330 | |||
| Name | BDBM50092330 | ||
| Synonyms: | CHEMBL3581649 | US9675697, RX-3 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C17H14ClN3O2 | ||
| Mol. Mass. | 327.765 | ||
| SMILES | COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(Cl)c21 |(5.4,2.98,;5.4,1.69,;4.01,.88,;2.65,1.65,;1.32,.88,;1.32,-.65,;2.65,-1.41,;4.01,-.65,;5.4,-1.46,;5.55,-3.05,;4.58,-3.9,;7.12,-3.38,;7.92,-1.99,;6.85,-.79,;7.11,.47,;,-1.41,;-1.32,-.65,;-2.67,-1.41,;-3.97,-.65,;-3.97,.88,;-2.67,1.65,;-2.68,2.94,;-1.32,.88,)| | ||
| Structure | 
| ||
| n/a | |||