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Target
Bromodomain-containing protein 3 [326-398]
Ligand
BDBM50092327
Substrate
n/a
Meas. Tech.
FP Competitive Binding Assay (No.350)
Temperature
298.15±n/a K
Ki
3438±1985 nM
Comments
extracted
Citation
 Wang, S; Ran, X; Zhao, Y; Yang, C; Liu, L; Bai, L; McEachern, D; Stuckey, J; Meagher, JL; Sun, D; Li, X; Zhou, B; Karatas, H; Luo, R; Chinnaiyan, A; Asangani, IA BET bromodomain inhibitors and therapeutic methods using the same US Patent  US9675697 Publication Date 6/13/2017 
Target
Name:
Bromodomain-containing protein 3 [326-398]
Synonyms:
BRD3 | BRD3_HUMAN | Bromodomain-containing protein 3 (BRD3)(BD2) | Bromodomain-containing protein 3 Bromo 2 domain(BRD3 BD2) | KIAA0043 | RING3L
Type:
n/a
Mol. Mass.:
8553.07
Organism:
Homo sapiens (Human)
Description:
BD2 (326-398 aa) of Q15059
Residue:
73
Sequence:
KHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVV
  
Inhibitor
Name:
BDBM50092327
Synonyms:
CHEMBL3581652 | US9675697, RX-45
Type:
Small organic molecule
Emp. Form.:
C19H18ClN3O2
Mol. Mass.:
355.818
SMILES:
CCc1noc(CC)c1-c1cc2[nH]c3ccnc(Cl)c3c2cc1OC |(4.56,-5.32,;4.3,-4.07,;5.49,-3.01,;7.04,-3.34,;7.84,-1.97,;6.77,-.78,;7.09,.77,;8.3,1.17,;5.34,-1.44,;3.96,-.64,;2.62,-1.4,;1.3,-.64,;,-1.4,;-1.3,-.64,;-2.64,-1.4,;-3.92,-.64,;-3.92,.87,;-2.64,1.63,;-2.65,2.9,;-1.3,.87,;1.3,.87,;2.62,1.63,;3.96,.87,;5.34,1.67,;5.34,2.95,)|
Structure:
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