Reaction Details Report a problem with these data
Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM312074
Substrate
n/a
Meas. Tech.
Assay for IDO1 Enzymatic Activity Determination
IC50
620±n/a nM
Citation
 Crosignani, S; Cauwenberghs, S; Driessens, G; Deroose, F Pyrrolidine-2, 5-dione derivatives, pharmaceutical compositions and methods for use as IDO1 inhibitors US Patent  US9603836 Publication Date 3/28/2017 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM312074
Synonyms:
(R)-3-(6-bromo-5- fluoro-1H-indol-3-yl)- pyrrolidine-2,5-dione | US9603836, Compound 10 | US9949951, 10
Type:
Small organic molecule
Emp. Form.:
C12H8BrFN2O2
Mol. Mass.:
311.107
SMILES:
Fc1cc2c(c[nH]c2cc1Br)[C@H]1CC(=O)NC1=O |r|
Structure:
Search PDB for entries with ligand similarity: