Reaction Details Report a problem with these data
Target
Apoptosis regulator Bcl-2
Ligand
BDBM177824
Substrate
n/a
Meas. Tech.
Fluorescence Polarisation Assay
IC50
110±n/a nM
Citation
 Le Diguarher, T; Casara, P; Starck, J; Henlin, J; Davidson, JE; Murray, JB; Graham, CJ; Chen, I; Geneste, O; Hickman, J; Depil, S; Le Tiran, A; Nyerges, M; De Nanteuil, G Indolizine compounds, a process for their preparation and pharmaceutical compositions containing them US Patent  US9603854 Publication Date 3/28/2017 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM177824
Synonyms:
US9120791, Example 43 | US9603854, 43
Type:
Small organic molecule
Emp. Form.:
C45H46ClN5O4
Mol. Mass.:
756.331
SMILES:
CN1CCc2cc(ccc12)N(C(=O)c1cc(c2CCCCn12)-c1cc(Cl)ccc1C(=O)N1Cc2ccccc2C[C@H]1CN1CCOCC1)c1ccc(O)cc1
Structure:
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