Target
Apoptosis regulator Bcl-2
Ligand
BDBM177872
Substrate
n/a
Meas. Tech.
Fluorescence Polarisation Assay
IC50
12±n/a nM
Citation
 Le Diguarher, TCasara, PStarck, JHenlin, JDavidson, JEMurray, JBGraham, CJChen, IGeneste, OHickman, JDepil, SLe Tiran, ANyerges, MDe Nanteuil, G Indolizine compounds, a process for their preparation and pharmaceutical compositions containing them US Patent  US9603854 Publication Date 3/28/2017 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM177872
Synonyms:
US9120791, Example 98 | US9603854, 98
Type:
Small organic molecule
Emp. Form.:
C42H40F2N4O5
Mol. Mass.:
718.7876
SMILES:
Cc1ccc(cc1F)N(C(=O)c1cc(-c2cc(F)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCOCc12)c1ccc(O)cc1
Structure:
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