Target
Apoptosis regulator Bcl-2
Ligand
BDBM177877
Substrate
n/a
Meas. Tech.
Fluorescence Polarisation Assay
IC50
7.00±n/a nM
Citation
 Le Diguarher, TCasara, PStarck, JHenlin, JDavidson, JEMurray, JBGraham, CJChen, IGeneste, OHickman, JDepil, SLe Tiran, ANyerges, MDe Nanteuil, G Indolizine compounds, a process for their preparation and pharmaceutical compositions containing them US Patent  US9603854 Publication Date 3/28/2017 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM177877
Synonyms:
US9120791, Example 104 | US9603854, 104
Type:
Small organic molecule
Emp. Form.:
C45H46N6O5
Mol. Mass.:
750.8839
SMILES:
COc1ccc(C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)c(c1)-c1cc(C(=O)N(c2ccc(O)cc2)c2ccc3n(C)ncc3c2)c2CCCCn12
Structure:
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