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Target
Tyrosine-protein kinase JAK2
Ligand
BDBM232752
Substrate
n/a
Meas. Tech.
JAK Enzyme Assay
Ki
0.180±n/a nM
Citation
 Zak, ME; Ray, NC; Goodacre, SC; Mendonca, R; Kellar, T; Cheng, Y; Li, W; Yuen, P 5-chloro-2-difluoromethoxyphenyl pyrazolopyrimidine compounds, compositions and methods of use thereof US Patent  US9604984 Publication Date 3/28/2017 
Target
Name:
Tyrosine-protein kinase JAK2
Synonyms:
JAK-2 | JAK2 | JAK2_HUMAN | Janus kinase 2 | Janus kinase 2 (JAK2) | Janus kinase 2 (a protein tyrosine kinase)
Type:
Protein
Mol. Mass.:
130684.68
Organism:
Homo sapiens (Human)
Description:
O60674
Residue:
1132
Sequence:
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM232752
Synonyms:
US9346815, 298 | US9604984, Example 298
Type:
Small organic molecule
Emp. Form.:
C22H21ClF2N8O2
Mol. Mass.:
502.904
SMILES:
CN[C@H]1C[C@H](C1)n1cc(NC(=O)c2c(N)nn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F |r,wU:2.1,4.6,(-6.44,-4.01,;-5.1,-4.78,;-3.77,-4.01,;-3.37,-2.52,;-1.88,-2.92,;-2.28,-4.41,;-.55,-2.15,;-.55,-.61,;.91,-.13,;1.31,1.35,;.22,2.44,;-1.26,2.04,;.62,3.93,;-.28,5.18,;-1.82,5.18,;.62,6.42,;2.09,5.95,;3.42,6.72,;4.75,5.95,;4.75,4.41,;3.42,3.64,;2.09,4.41,;1.82,-1.38,;.91,-2.63,;3.36,-1.38,;4.13,-.05,;5.67,-.05,;6.44,1.29,;6.44,-1.38,;5.67,-2.71,;4.13,-2.71,;3.36,-4.05,;4.13,-5.38,;3.36,-6.72,;5.67,-5.38,)|
Structure:
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