Reaction Details Report a problem with these data
Target
ATP-sensitive inward rectifier potassium channel 1
Ligand
BDBM312611
Substrate
n/a
Meas. Tech.
Electrophysiology Assay
IC50
150±n/a nM
Citation
 Pasternak, A; DeJesus, RK; Ding, F; Dong, S; Frie, JL; Gu, X; Jiang, J; Shahripour, A; Pio, B; Tang, H; Walsh, S Inhibitors of the renal outer medullary potassium channel US Patent  US9604998 Publication Date 3/28/2017 
Target
Name:
ATP-sensitive inward rectifier potassium channel 1
Synonyms:
ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44809.08
Organism:
Homo sapiens (Human)
Description:
gi_223460826
Residue:
391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
  
Inhibitor
Name:
BDBM312611
Synonyms:
US9604998, Example 17 | US9604998, Example 18
Type:
Small organic molecule
Emp. Form.:
C23H25FN8O2
Mol. Mass.:
464.4954
SMILES:
Cc1c(ccc(F)c1[N+]#[C-])[C@H]1CN2CCN(CC(O)c3ccc(nc3)-n3cnnn3)C[C@H]2CO1 |r|
Structure:
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