Reaction Details Report a problem with these data
Target
ATP-sensitive inward rectifier potassium channel 1
Ligand
BDBM312686
Substrate
n/a
Meas. Tech.
Electrophysiology Assay
IC50
90.0±n/a nM
Citation
 Pasternak, A; DeJesus, RK; Ding, F; Dong, S; Frie, JL; Gu, X; Jiang, J; Shahripour, A; Pio, B; Tang, H; Walsh, S Inhibitors of the renal outer medullary potassium channel US Patent  US9604998 Publication Date 3/28/2017 
Target
Name:
ATP-sensitive inward rectifier potassium channel 1
Synonyms:
ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44809.08
Organism:
Homo sapiens (Human)
Description:
gi_223460826
Residue:
391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
  
Inhibitor
Name:
BDBM312686
Synonyms:
US9604998, Example 85
Type:
Small organic molecule
Emp. Form.:
C27H31N3O4
Mol. Mass.:
461.5527
SMILES:
COc1cc(CCN2CCN3C[C@H](OC[C@@H]3C2)c2ccc3C(=O)O[C@@H](C)Cc3c2)ccc1C#N |r|
Structure:
Search PDB for entries with ligand similarity: