Reaction Details Report a problem with these data
Target
Nicotinamide phosphoribosyltransferase
Ligand
BDBM180125
Substrate
n/a
Meas. Tech.
Biochemical Inhibition Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
11±n/a nM
Comments
extracted
Citation
 Bair, KW; Buckmelter, AJ; Han, B; Lin, J; Reynolds, DJ; Smith, CC; Wang, Z; Zheng, X Compounds and compositions for the inhibition of NAMPT US Patent  US9676721 Publication Date 6/13/2017 
Target
Name:
Nicotinamide phosphoribosyltransferase
Synonyms:
NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1
Type:
Enzyme
Mol. Mass.:
55524.98
Organism:
Homo sapiens (Human)
Description:
P43490
Residue:
491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH
  
Inhibitor
Name:
BDBM180125
Synonyms:
US9676721, 31 2-cyano-1-({4-[(3,5-dichlorobenzene)sulfonyl]phenyl}methyl)-3-(pyridin-4-yl)guanidine
Type:
Small organic molecule
Emp. Form.:
C20H15Cl2N5O2S
Mol. Mass.:
460.336
SMILES:
Clc1cc(Cl)cc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1 |w:25.27|
Structure:
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