Target
Nicotinamide phosphoribosyltransferase
Ligand
BDBM180922
Substrate
n/a
Meas. Tech.
Biochemical Inhibition Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
2.50±n/a nM
Comments
extracted
Citation
 Bair, KWBuckmelter, AJHan, BLin, JReynolds, DJSmith, CCWang, ZZheng, X Compounds and compositions for the inhibition of NAMPT US Patent  US9676721 Publication Date 6/13/2017 
Target
Name:
Nicotinamide phosphoribosyltransferase
Synonyms:
NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1
Type:
Enzyme
Mol. Mass.:
55524.98
Organism:
Homo sapiens (Human)
Description:
P43490
Residue:
491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH
  
Inhibitor
Name:
BDBM180922
Synonyms:
US9676721, 53 2-cyano-1-({4-[(4-methylbenzene)sulfonyl]phenyl}methyl)-3-(pyridin-4-yl)guanidine
Type:
Small organic molecule
Emp. Form.:
C21H19N5O2S
Mol. Mass.:
405.473
SMILES:
Cc1ccc(cc1)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
Structure:
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