Reaction Details Report a problem with these data
Target
Nicotinamide phosphoribosyltransferase
Ligand
BDBM180854
Substrate
n/a
Meas. Tech.
Biochemical Inhibition Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
2.10±n/a nM
Comments
extracted
Citation
Bair, KW; Buckmelter, AJ; Han, B; Lin, J; Reynolds, DJ; Smith, CC; Wang, Z; Zheng, X Compounds and compositions for the inhibition of NAMPT US Patent US9676721 Publication Date 6/13/2017
More Info.:
Target
Name:
Nicotinamide phosphoribosyltransferase
Synonyms:
NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1
Type:
Enzyme
Mol. Mass.:
55524.98
Organism:
Homo sapiens (Human)
Description:
P43490
Residue:
491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH
Inhibitor
Name:
BDBM180854
Synonyms:
US9676721, 69 2-cyano-1-[(4-{[3-(propane-1-sulfonamido)benzene]sulfonyl}phenyl)methyl]-3-(pyridin-4-yl)guanidine
Type:
Small organic molecule
Emp. Form.:
C23H24N6O4S2
Mol. Mass.:
512.604
SMILES:
CCCS(=O)(=O)Nc1cccc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1 |w:30.32|