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TargetNicotinamide phosphoribosyltransferase (NAMPT)
LigandBDBM180921
Substrate/Competitorn/a
Meas. Tech.Biochemical Inhibition Assay
pH7.5±n/a
Temperature298.15±n/a K
IC50 1.00±n/a nM
Commentsextracted
Citation Bair, KWBuckmelter, AJHan, BLin, JReynolds, DJSmith, CCWang, ZZheng, X Compounds and compositions for the inhibition of NAMPT US Patent US9676721 Publication Date 6/13/2017
More Info.:Get all data from this article,  Assay Method
 
Nicotinamide phosphoribosyltransferase (NAMPT)
Name:Nicotinamide phosphoribosyltransferase
Synonyms:NAmPRTase | Nicotinamide phosphoribosyltransferase (NAMPT) | Pre-B-cell colony-enhancing factor 1
Type:Enzyme
Mol. Mass.:55524.98
Organism:Homo sapiens (Human)
Description:P43490
Residue:491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVP
EGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNA
QLNIELEAAHH
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  Blast E-value cutoff:
BDBM180921
NameBDBM180921
Synonyms:US9676721, 79 2-cyano-1-{[4-(1-methyl-1H-indazole-6-sulfonyl)phenyl]methyl}-3-(pyridin-4-yl)guanidine
TypeSmall organic molecule
Emp. Form.C22H19N7O2S
Mol. Mass.445.497
SMILESCn1ncc2ccc(cc12)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
Structure
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