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Target
Caspase-9
Ligand
BDBM10315
Substrate
Caspase-9 Fluorogenic Substrate
Meas. Tech.
Caspase Inhibition Assay
Ki
850±n/a nM
Citation
 Lee, D; Long, SA; Murray, JH; Adams, JL; Nuttall, ME; Nadeau, DP; Kikly, K; Winkler, JD; Sung, CM; Ryan, MD; Levy, MA; Keller, PM; DeWolf, WE Potent and selective nonpeptide inhibitors of caspases 3 and 7. J Med Chem 44:2015-26 (2001) [PubMed]  Article 
Target
Name:
Caspase-9
Synonyms:
Apoptotic protease-activating factor 1/Caspase-3/Caspase-9/Cytochrome c | Apoptotic protease-activating factor 3 | CASP-9 | CASP9 | CASP9_HUMAN | Caspase 9 | ICE-like apoptotic protease 6 | MCH6 | caspase-9 isoform alpha preproprotein
Type:
Enzyme
Mol. Mass.:
46277.29
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
416
Sequence:
MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
  
Inhibitor
Name:
BDBM10315
Synonyms:
(S)-5-{1-[2-(Anilinomethyl)pyrrolidinyl]sulfonyl}isatin | 5-{[(2S)-2-[(phenylamino)methyl]pyrrolidine-1-]sulfonyl}-2,3-dihydro-1H-indole-2,3-dione | Isatin Sulfonamide 26
Type:
Small organic molecule
Emp. Form.:
C19H19N3O4S
Mol. Mass.:
385.437
SMILES:
O=C1Nc2ccc(cc2C1=O)S(=O)(=O)N1CCC[C@H]1CNc1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Caspase-9 Fluorogenic Substrate
Synonyms:
Ac-LEHD-AFC
Type:
n/a
Mol. Mass.:
1518.25
Organism:
n/a
Description:
AFC=7-Amino-4-trifluoromethylcoumarin
Residue:
15
Sequence:
ACLEGLHISASPAFC