Target
Sphingosine-1-phosphate lyase 1
Ligand
BDBM65202
Substrate
n/a
Meas. Tech.
hS1P1 ERK Phosphorylation (S1P1 pERK)
EC50
<10±n/a nM
Citation
 Dyckman, AJDhar, TGXiao, HGilmore, JLYang, MGXiao, ZMarcoux, D Substituted bicyclic compounds US Patent  US10166249 Publication Date 1/1/2019 
Target
Name:
Sphingosine-1-phosphate lyase 1
Synonyms:
KIAA1252 | S1PL | SGPL1 | SGPL1_HUMAN | SP-lyase 1 | SPL 1 | Sphingosine-1-phosphate aldolase | hSPL
Type:
PROTEIN
Mol. Mass.:
63546.76
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108363
Residue:
568
Sequence:
MPSTDLLMLKAFEPYLEILEVYSTKAKNYVNGHCTKYEPWQLIAWSVVWTLLIVWGYEFVFQPESLWSRFKKKCFKLTRKMPIIGRKIQDKLNKTKDDISKNMSFLKVDKEYVKALPSQGLSSSAVLEKLKEYSSMDAFWQEGRASGTVYSGEEKLTELLVKAYGDFAWSNPLHPDIFPGLRKIEAEIVRIACSLFNGGPDSCGCVTSGGTESILMACKAYRDLAFEKGIKTPEIVAPQSAHAAFNKAASYFGMKIVRVPLTKMMEVDVRAMRRAISRNTAMLVCSTPQFPHGVIDPVPEVAKLAVKYKIPLHVDACLGGFLIVFMEKAGYPLEHPFDFRVKGVTSISADTHKYGYAPKGSSLVLYSDKKYRNYQFFVDTDWQGGIYASPTIAGSRPGGISAACWAALMHFGENGYVEATKQIIKTARFLKSELENIKGIFVFGNPQLSVIALGSRDFDIYRLSNLMTAKGWNLNQLQFPPSIHFCITLLHARKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQTTVDRNMVAELSSVFLDSLYSTDTVTQGSQMNGSPKPH
  
Inhibitor
Name:
BDBM65202
Synonyms:
US10166249, Example 543 | US9522888, 543
Type:
n/a
Emp. Form.:
C22H36NO5P
Mol. Mass.:
425.4987
SMILES:
CC(C)COCC[C@H]1CCc2cc(ccc2C1)[C@H]1CC[C@](N)(COP(O)(O)=O)C1 |r|
Structure:
Search PDB for entries with ligand similarity: