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Target
Abscisic acid receptor PYL1/Protein phosphatase 2C 16
Ligand
BDBM313208
Substrate
n/a
Meas. Tech.
PP2C Activity Assay
IC50
200±n/a nM
Citation
 Loiseleur, O; Wendeborn, SV; Cutler, SR 2-oxo-3,4-dihydroquinolin-6-yl sulphonamide CPDS and their use as plant growth regulators US Patent  US10167261 Publication Date 1/1/2019 
Target
Name:
Abscisic acid receptor PYL1/Protein phosphatase 2C 16
Synonyms:
PYR1-HAB1
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Protein phosphatase 2C 16
Synonyms:
AtP2C-HA | AtPP2C16 | HAB1 | P2C-HA | P2C16_ARATH | PP2C HAB1 | Protein HYPERSENSITIVE TO ABA 1 | Protein phosphatase 2C HAB1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55716.72
Organism:
Arabidopsis thaliana (Mouse-ear cress)
Description:
n/a
Residue:
511
Sequence:
MEEMTPAVAMTLSLAANTMCESSPVEITQLKNVTDAADLLSDSENQSFCNGGTECTMEDVSELEEVGEQDLLKTLSDTRSGSSNVFDEDDVLSVVEDNSAVISEGLLVVDAGSELSLSNTAMEIDNGRVLATAIIVGESSIEQVPTAEVLIAGVNQDTNTSEVVIRLPDENSNHLVKGRSVYELDCIPLWGTVSIQGNRSEMEDAFAVSPHFLKLPIKMLMGDHEGMSPSLTHLTGHFFGVYDGHGGHKVADYCRDRLHFALAEEIERIKDELCKRNTGEGRQVQWDKVFTSCFLTVDGEIEGKIGRAVVGSSDKVLEAVASETVGSTAVVALVCSSHIVVSNCGDSRAVLFRGKEAMPLSVDHKPDREDEYARIENAGGKVIQWQGARVFGVLAMSRSIGDRYLKPYVIPEPEVTFMPRSREDECLILASDGLWDVMNNQEVCEIARRRILMWHKKNGAPPLAERGKGIDPACQAAADYLSMLALQKGSKDNISIIVIDLKAQRKFKTRT
  
Component 2
Name:
Abscisic acid receptor PYL1
Synonyms:
ABI1-binding protein 6 | PYL1 | PYL1_ARATH | PYR1-like protein 1 | RCAR12 | Regulatory components of ABA receptor 9
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25355.15
Organism:
Arabidopsis thaliana (Mouse-ear cress)
Description:
n/a
Residue:
221
Sequence:
MANSESSSSPVNEEENSQRISTLHHQTMPSDLTQDEFTQLSQSIAEFHTYQLGNGRCSSLLAQRIHAPPETVWSVVRRFDRPQIYKHFIKSCNVSEDFEMRVGCTRDVNVISGLPANTSRERLDLLDDDRRVTGFSITGGEHRLRNYKSVTTVHRFEKEEEEERIWTVVLESYVVDVPEGNSEEDTRLFADTVIRLNLQKLASITEAMNRNNNNNNSSQVR
  
Inhibitor
Name:
BDBM313208
Synonyms:
1-(4-cyclopropylphenyl)-N-(1-ethyl-4-methyl-2-oxo-3,4-dihydroquinolin-6-yl)methanesulfonamide | US10167261, Compound 1.178
Type:
Small organic molecule
Emp. Form.:
C22H26N2O3S
Mol. Mass.:
398.518
SMILES:
CCN1C(=O)CC(C)c2cc(NS(=O)(=O)Cc3ccc(cc3)C3CC3)ccc12
Structure:
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