Reaction Details Report a problem with these data
Target
Abscisic acid receptor PYL2/Protein phosphatase 2C 16
Ligand
BDBM313209
Substrate
n/a
Meas. Tech.
PP2C Activity Assay
IC50
64.0±n/a nM
Citation
 Loiseleur, O; Wendeborn, SV; Cutler, SR 2-oxo-3,4-dihydroquinolin-6-yl sulphonamide CPDS and their use as plant growth regulators US Patent  US10167261 Publication Date 1/1/2019 
Target
Name:
Abscisic acid receptor PYL2/Protein phosphatase 2C 16
Synonyms:
PYR2-HAB1
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Protein phosphatase 2C 16
Synonyms:
AtP2C-HA | AtPP2C16 | HAB1 | P2C-HA | P2C16_ARATH | PP2C HAB1 | Protein HYPERSENSITIVE TO ABA 1 | Protein phosphatase 2C HAB1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55716.72
Organism:
Arabidopsis thaliana (Mouse-ear cress)
Description:
n/a
Residue:
511
Sequence:
MEEMTPAVAMTLSLAANTMCESSPVEITQLKNVTDAADLLSDSENQSFCNGGTECTMEDVSELEEVGEQDLLKTLSDTRSGSSNVFDEDDVLSVVEDNSAVISEGLLVVDAGSELSLSNTAMEIDNGRVLATAIIVGESSIEQVPTAEVLIAGVNQDTNTSEVVIRLPDENSNHLVKGRSVYELDCIPLWGTVSIQGNRSEMEDAFAVSPHFLKLPIKMLMGDHEGMSPSLTHLTGHFFGVYDGHGGHKVADYCRDRLHFALAEEIERIKDELCKRNTGEGRQVQWDKVFTSCFLTVDGEIEGKIGRAVVGSSDKVLEAVASETVGSTAVVALVCSSHIVVSNCGDSRAVLFRGKEAMPLSVDHKPDREDEYARIENAGGKVIQWQGARVFGVLAMSRSIGDRYLKPYVIPEPEVTFMPRSREDECLILASDGLWDVMNNQEVCEIARRRILMWHKKNGAPPLAERGKGIDPACQAAADYLSMLALQKGSKDNISIIVIDLKAQRKFKTRT
  
Component 2
Name:
Abscisic acid receptor PYL2
Synonyms:
PYL2 | PYL2_ARATH | PYR1-like protein 2 | RCAR14 | Regulatory components of ABA receptor 14
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21277.66
Organism:
Arabidopsis thaliana (Mouse-ear cress)
Description:
n/a
Residue:
190
Sequence:
MSSSPAVKGLTDEEQKTLEPVIKTYHQFEPDPTTCTSLITQRIHAPASVVWPLIRRFDNPERYKHFVKRCRLISGDGDVGSVREVTVISGLPASTSTERLEFVDDDHRVLSFRVVGGEHRLKNYKSVTSVNEFLNQDSGKVYTVVLESYTVDIPEGNTEEDTKMFVDTVVKLNLQKLGVAATSAPMHDDE
  
Inhibitor
Name:
BDBM313209
Synonyms:
US10167261, Compound 1.179
Type:
Small organic molecule
Emp. Form.:
C23H28N2O3S
Mol. Mass.:
412.545
SMILES:
CCCN1C(=O)CC(C)c2cc(NS(=O)(=O)Cc3ccc(cc3)C3CC3)ccc12
Structure:
Search PDB for entries with ligand similarity: