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Target
Prokineticin receptor 1
Ligand
BDBM250562
Substrate
n/a
Meas. Tech.
BIOLOGICAL ASSAY
IC50
5900±n/a nM
Citation
 Carroll, C; Goldby, A; Teall, M Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases US Patent  US10167273 Publication Date 1/1/2019 
Target
Name:
Prokineticin receptor 1
Synonyms:
G-protein coupled receptor 73 | G-protein coupled receptor ZAQ | GPR73 | GPR73a | PK-R1 | PKR1 | PKR1_HUMAN | PROKR1
Type:
enzyme
Mol. Mass.:
44779.92
Organism:
Homo sapiens (Human)
Description:
Q8TCW9
Residue:
393
Sequence:
METTMGFMDDNATNTSTSFLSVLNPHGAHATSFPFNFSYSDYDMPLDEDEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFIAALVRYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCTSVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTATGLIALVWTVSILIAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYIVECIAMSNSMINTLCFVTVKNDTVKYFKKIMLLHWKASYNGGKSSADLDLKTIGMPATEEVDCIRLK
  
Inhibitor
Name:
BDBM250562
Synonyms:
US10167273, Example 41 | US10544126, Example 41 | US11512066, Example 41 | US9475795, 41
Type:
Small organic molecule
Emp. Form.:
C17H22FN3O4S
Mol. Mass.:
383.438
SMILES:
COc1ccc(OC2CCN(CC2)S(=O)(=O)c2c(C)n[nH]c2C)cc1F
Structure:
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