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Target
Metabotropic glutamate receptor 4
Ligand
BDBM182882
Substrate
n/a
Meas. Tech.
Ca2+ Mobilization In Vitro Assay
EC50
152±n/a nM
Citation
 Biemans, B; Guba, W; Jaeschke, G; Ricci, A; Rueher, D; Vieira, E Ethynyl derivatives US Patent  US9676732 Publication Date 6/13/2017 
Target
Name:
Metabotropic glutamate receptor 4
Synonyms:
GPRC1D | GRM4 | GRM4_HUMAN | Glutamate receptor, metabotropic 4 | MGLUR4 | Metabotropic glutamate receptor 4 | Metabotropic glutamate receptor 4 (mGlu4) | Metabotropic glutamate receptor 4 (mGluR4) | metabotropic glutamate 4
Type:
Protein
Mol. Mass.:
101899.95
Organism:
Homo sapiens (Human)
Description:
Q14833
Residue:
912
Sequence:
MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALATKQTYVTYTNHAI
  
Inhibitor
Name:
BDBM182882
Synonyms:
US9676732, 16 3-[2-Chloro-4-(2-phenylethynyl)phenyl]-1H-pyrimido[4,5-d]pyrimidine-2,4-dione
Type:
Small organic molecule
Emp. Form.:
C20H11ClN4O2
Mol. Mass.:
374.78
SMILES:
Clc1cc(ccc1-n1c(=O)[nH]c2ncncc2c1=O)C#Cc1ccccc1 |(-0,3.85,;-0,2.31,;-1.33,1.54,;-1.33,-0,;-0,-.77,;1.33,-0,;1.33,1.54,;2.67,2.31,;2.67,3.85,;1.33,4.62,;4,4.62,;5.33,3.85,;6.67,4.62,;8,3.85,;8,2.31,;6.67,1.54,;5.33,2.31,;4,1.54,;4,0,;-2.67,-.77,;-4,-1.54,;-5.33,-2.31,;-6.67,-1.54,;-8,-2.31,;-8,-3.85,;-6.67,-4.62,;-5.33,-3.85,)|
Structure:
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