Reaction Details Report a problem with these data
Target
Metabotropic glutamate receptor 4
Ligand
BDBM182901
Substrate
n/a
Meas. Tech.
Ca2+ Mobilization In Vitro Assay
EC50
30±n/a nM
Citation
 Biemans, B; Guba, W; Jaeschke, G; Ricci, A; Rueher, D; Vieira, E Ethynyl derivatives US Patent  US9676732 Publication Date 6/13/2017 
Target
Name:
Metabotropic glutamate receptor 4
Synonyms:
GPRC1D | GRM4 | GRM4_HUMAN | Glutamate receptor, metabotropic 4 | MGLUR4 | Metabotropic glutamate receptor 4 | Metabotropic glutamate receptor 4 (mGlu4) | Metabotropic glutamate receptor 4 (mGluR4) | metabotropic glutamate 4
Type:
Protein
Mol. Mass.:
101899.95
Organism:
Homo sapiens (Human)
Description:
Q14833
Residue:
912
Sequence:
MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALATKQTYVTYTNHAI
  
Inhibitor
Name:
BDBM182901
Synonyms:
US9676732, 35 6-[2,6-Difluoro-4-(2-phenylethynyl)phenyl]-4-isopropyl-2-methyl-pyrazolo[4,3-d]pyrimidine-5,7-dione
Type:
Small organic molecule
Emp. Form.:
C23H18F2N4O2
Mol. Mass.:
420.4114
SMILES:
CC(C)n1c2cn(C)nc2c(=O)n(-c2c(F)cc(cc2F)C#Cc2ccccc2)c1=O |(4.71,5.78,;3.38,5,;2.05,5.78,;3.38,3.47,;4.71,2.69,;6.18,3.17,;7.08,1.93,;8.62,1.93,;6.18,.68,;4.71,1.15,;3.38,.38,;3.38,-1.15,;2.05,1.15,;.71,.38,;.71,-1.15,;2.05,-1.93,;-.62,-1.93,;-1.95,-1.15,;-1.95,.38,;-.62,1.15,;-.62,2.69,;-3.29,-1.93,;-4.62,-2.69,;-5.96,-3.47,;-7.29,-2.69,;-8.62,-3.47,;-8.62,-5,;-7.29,-5.78,;-5.96,-5,;2.05,2.69,;.71,3.47,)|
Structure:
Search PDB for entries with ligand similarity: