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Target
Metabotropic glutamate receptor 4
Ligand
BDBM182930
Substrate
n/a
Meas. Tech.
Ca2+ Mobilization In Vitro Assay
EC50
121±n/a nM
Citation
 Biemans, B; Guba, W; Jaeschke, G; Ricci, A; Rueher, D; Vieira, E Ethynyl derivatives US Patent  US9676732 Publication Date 6/13/2017 
Target
Name:
Metabotropic glutamate receptor 4
Synonyms:
GPRC1D | GRM4 | GRM4_HUMAN | Glutamate receptor, metabotropic 4 | MGLUR4 | Metabotropic glutamate receptor 4 | Metabotropic glutamate receptor 4 (mGlu4) | Metabotropic glutamate receptor 4 (mGluR4) | metabotropic glutamate 4
Type:
Protein
Mol. Mass.:
101899.95
Organism:
Homo sapiens (Human)
Description:
Q14833
Residue:
912
Sequence:
MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALATKQTYVTYTNHAI
  
Inhibitor
Name:
BDBM182930
Synonyms:
US9676732, 64 5-[2,6-Difluoro-4-(2-phenylethynyl)phenyl]-7-isopropyl-2H-pyrazolo[3,4-d]pyrimidine-4,6-dione
Type:
Small organic molecule
Emp. Form.:
C22H16F2N4O2
Mol. Mass.:
406.3848
SMILES:
CC(C)n1c2n[nH]cc2c(=O)n(-c2c(F)cc(cc2F)C#Cc2ccccc2)c1=O |(2.82,5.77,;4.15,5,;5.48,5.77,;4.15,3.46,;5.48,2.7,;6.95,3.17,;7.85,1.93,;6.95,.68,;5.48,1.16,;4.15,.39,;4.15,-1.15,;2.82,1.16,;1.48,.39,;.15,1.15,;.15,2.69,;-1.19,.39,;-1.19,-1.15,;.15,-1.92,;1.48,-1.15,;2.82,-1.93,;-2.52,-1.92,;-3.85,-2.69,;-5.19,-3.46,;-6.52,-2.69,;-7.85,-3.46,;-7.85,-5,;-6.52,-5.77,;-5.19,-5,;2.82,2.7,;1.48,3.47,)|
Structure:
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