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Target
Metabotropic glutamate receptor 4
Ligand
BDBM182937
Substrate
n/a
Meas. Tech.
Ca2+ Mobilization In Vitro Assay
EC50
86±n/a nM
Citation
 Biemans, B; Guba, W; Jaeschke, G; Ricci, A; Rueher, D; Vieira, E Ethynyl derivatives US Patent  US9676732 Publication Date 6/13/2017 
Target
Name:
Metabotropic glutamate receptor 4
Synonyms:
GPRC1D | GRM4 | GRM4_HUMAN | Glutamate receptor, metabotropic 4 | MGLUR4 | Metabotropic glutamate receptor 4 | Metabotropic glutamate receptor 4 (mGlu4) | Metabotropic glutamate receptor 4 (mGluR4) | metabotropic glutamate 4
Type:
Protein
Mol. Mass.:
101899.95
Organism:
Homo sapiens (Human)
Description:
Q14833
Residue:
912
Sequence:
MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALATKQTYVTYTNHAI
  
Inhibitor
Name:
BDBM182937
Synonyms:
US9676732, 71 3-[2-Chloro-6-fluoro-4-[2-(3-pyridyl)ethynyl]phenyl]-1-(oxetan-3-yl)quinazoline-2,4-dione
Type:
Small organic molecule
Emp. Form.:
C24H15ClFN3O3
Mol. Mass.:
447.846
SMILES:
Fc1cc(cc(Cl)c1-n1c(=O)n(C2COC2)c2ccccc2c1=O)C#Cc1cccnc1 |(2.67,-2.63,;1.33,-1.86,;-0,-2.63,;-1.33,-1.86,;-1.33,-.32,;-0,.45,;-0,1.99,;1.33,-.32,;2.67,.45,;2.67,1.99,;1.33,2.76,;4,2.76,;4,4.3,;5.09,5.39,;4,6.48,;2.91,5.39,;5.33,1.99,;6.67,2.76,;8,1.99,;8,.45,;6.67,-.32,;5.33,.45,;4,-.32,;4,-1.86,;-2.67,-2.63,;-4,-3.4,;-5.33,-4.17,;-5.33,-5.71,;-6.67,-6.48,;-8,-5.71,;-8,-4.17,;-6.67,-3.4,)|
Structure:
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