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Target
Tyrosine-protein kinase JAK3 [811-1124]
Ligand
BDBM264195
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Studies
IC50
>30000±n/a nM
Citation
 Astrand, A; Grimster, N; Kawatkar, S; Kettle, JG; Nilsson, MK; Ruston, L; Su, Q; Vasbinder, M; Winter-Holt, JJ; Woessner, RD; Chuaqui, CE; McCabe, J Compounds and methods for inhibiting JAK US Patent  US10167276 Publication Date 1/1/2019 
Target
Name:
Tyrosine-protein kinase JAK3 [811-1124]
Synonyms:
JAK3 | JAK3 (aa 811-1124) | JAK3_HUMAN | Tyrosine-protein kinase JAK3 (aa 811-1124)
Type:
Protein
Mol. Mass.:
35601.85
Organism:
Homo sapiens (Human)
Description:
P52333[811-1124]
Residue:
314
Sequence:
CQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS
  
Inhibitor
Name:
BDBM264195
Synonyms:
(2R)-2-(4-ethylpiperazin- 1-yl)-N-(3- {2-[(3-methoxy-1- methyl-1H-pyrazol-4-yl) amino]-5- methylpyrimidin-4-yl}- 1H-indol-7-yl)propanamide | US10167276, Example 16 | US10654835, Example 16 | US11247983, Example 16 | US9714236, 16
Type:
Small organic molecule
Emp. Form.:
C27H35N9O2
Mol. Mass.:
517.6259
SMILES:
CCN1CCN(CC1)[C@H](C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1C |r|
Structure:
Search PDB for entries with ligand similarity: