Target
RAF proto-oncogene serine/threonine-protein kinase
Ligand
BDBM313601
Substrate
n/a
Meas. Tech.
In Vitro Raf Activity Determination
IC50
20.0±n/a nM
Citation
 Aversa, RJBurger, MTDillon, MPDineen, Jr., TALou, YNishiguchi, GARamurthy, SRico, ACRauniyar, VSendzik, MSubramanian, SSetti, LQTaft, BRTanner, HRWan, L Compounds and compositions as RAF kinase inhibitors US Patent  US10167279 Publication Date 1/1/2019 
Target
Name:
RAF proto-oncogene serine/threonine-protein kinase
Synonyms:
C-Raf Protein Kinase | Proto-oncogene c-RAF (RAF1) | RAF | RAF proto-oncogene serine/threonine-protein kinase (C-Raf) | RAF1 | RAF1_HUMAN | Raf-1 | Serine/threonine-protein kinase RAF | Serine/threonine-protein kinase C-Raf | cRaf
Type:
Serine/threonine-protein kinase
Mol. Mass.:
73082.52
Organism:
Homo sapiens (Human)
Description:
P04049
Residue:
648
Sequence:
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
  
Inhibitor
Name:
BDBM313601
Synonyms:
2-(1,1-difluoroethyl)-N- (3-(6-ethoxy-5- (tetrahydro-2H-pyran-4- yl)pyridazin-3-yl)-4- methylphenyl) isonicotinamide | US10167279, Example 225
Type:
Small organic molecule
Emp. Form.:
C26H28F2N4O3
Mol. Mass.:
482.5223
SMILES:
CCOc1nnc(cc1C1CCOCC1)-c1cc(NC(=O)c2ccnc(c2)C(C)(F)F)ccc1C
Structure:
Search PDB for entries with ligand similarity: