Reaction Details Report a problem with these data
Target
P2X purinoceptor 7
Ligand
BDBM267098
Substrate
n/a
Meas. Tech.
Screen Quest Fluo-8 No Wash Calcium Assay
IC50
32.0±n/a nM
Citation
 Pevarello, P; Lohmer, S; Llberati, C; Seneci, P; Pesenti, C; Prandi, A Substituted thiazole or oxazole P2X7 receptor antagonists US Patent  US10167281 Publication Date 1/1/2019 
Target
Name:
P2X purinoceptor 7
Synonyms:
ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor
Type:
Protein
Mol. Mass.:
68602.85
Organism:
Homo sapiens (Human)
Description:
Q99572
Residue:
595
Sequence:
MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISSVHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCPEYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPALLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGDNFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYKENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSSNCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRSLQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCGSCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDSTNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
  
Inhibitor
Name:
BDBM267098
Synonyms:
N-[2-(4,4-difluoropiperidin-1-yl)-2-(4-methyl-1,3-thiazol-5-yl)ethyl]-2-fluoro-5-(5-fluoropyrimidin-2-yl)benzamide | US10167281, Compound 70 | US9718812, 70
Type:
Small organic molecule
Emp. Form.:
C22H21F4N5OS
Mol. Mass.:
479.494
SMILES:
Cc1ncsc1C(CNC(=O)c1cc(ccc1F)-c1ncc(F)cn1)N1CCC(F)(F)CC1
Structure:
Search PDB for entries with ligand similarity: