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Target
Bromodomain-containing protein 4 [368-440]
Ligand
BDBM313786
Substrate
n/a
Meas. Tech.
Binding Assay
IC50
550±n/a nM
Citation
 Burns, C; Garnier, J; Sharp, PP; Feutrill, J; Cuzzupe, A Benzodiazepines as bromodomain inhibitors US Patent  US10167292 Publication Date 1/1/2019 
Target
Name:
Bromodomain-containing protein 4 [368-440]
Synonyms:
BRD4 | BRD4_HUMAN | Bromo domain 2 | Bromodomain-containing protein 4 (BD2) | Bromodomain-containing protein 4 (BRD4) Bromo 2 | Bromodomain-containing protein 4 (BRD4)(BD2) | Bromodomain-containing protein 4 (BRD4)(Bromo 2) | Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2) | Bromodomain-containing protein 4 Bromodomain 2 (BRD4-2) | Bromodomain-containing protein 4 Domain 2 | HUNK1
Type:
Protein
Mol. Mass.:
8564.63
Organism:
Homo sapiens (Human)
Description:
BD2 (368-440 aa) of O60885
Residue:
73
Sequence:
KHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVV
  
Inhibitor
Name:
BDBM313786
Synonyms:
US10167292, Example 30
Type:
Small organic molecule
Emp. Form.:
C23H26ClN5O
Mol. Mass.:
423.938
SMILES:
Cc1nnn2CCN(c3ccc(Cl)cc3)c3cc(CCN4CCOCC4)ccc3-c12
Structure:
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