Reaction Details
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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779]
Ligand
BDBM164288
Substrate
n/a
Meas. Tech.
PDE10A Inhibition Assay
Temperature
298.15±n/a K
IC50
46±n/a nM
Comments
extracted
Citation
Püschl, A; Nielsen, J; Kehler, J; Kilburn, JP; Marigo, M; Langgård, M Heteroaromatic phenylimidazole derivatives as PDE10A enzyme inhibitors US Patent US9669029 Publication Date 6/6/2017 More Info.:
Target
Name:
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779]
Synonyms:
PDE10A | PDE10_HUMAN | PED10A | Phosphodiesterase 10A (PDE10A)
Type:
n/a
Mol. Mass.:
39060.01
Organism:
Homo sapiens (Human)
Description:
Q9Y233[440-779]
Residue:
340
Sequence:
ICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED
Inhibitor
Name:
BDBM164288
Synonyms:
US9669029, 38 2-{(E)-2-[4-Furan-2-yl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-vinyl}-5-methyl-[1,2,4]triazolo[1,5-a]pyridine
Type:
Small organic molecule
Emp. Form.:
C22H29N5O2Si
Mol. Mass.:
423.5835
SMILES:
CC1=CC=CC2NC(\C=C/c3nc(cn3COCC[Si](C)(C)C)-c3ccco3)=NN12 |c:3,29,t:1|
Structure:
