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TargetBaculoviral IAP repeat-containing protein 2
LigandBDBM314219
Substrate/Competitorn/a
Meas. Tech.TR-FRET Assay
IC50 56.0±n/a nM
Citation Han, XLou, YMichoud, CMischke, SGRemiszewski, SRupert, KC Antiproliferative benzo [B] azepin-2-ones US Patent US9611224 Publication Date 4/4/2017
More Info.:Get all data from this article,  Assay Method
 
Baculoviral IAP repeat-containing protein 2
Name:Baculoviral IAP repeat-containing protein 2
Synonyms:Baculoviral IAP repeat-containing protein 2 (cIAP1) | Cellular inhibitor of apoptosis 1 | Inhibitor of apoptosis protein 2 (cIAP1)
Type:Protein
Mol. Mass.:69900.47
Organism:Homo sapiens (Human)
Description:Q13490
Residue:618
Sequence:
MHKTASQRLFPGPSYQNIKSIMEDSTILSDWTNSNKQKMKYDFSCELYRMSTYSTFPAGV
PVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCSFIQNLVSAS
LGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRAVEDISSSRTNPYSYA
MSTEEARFLTYHMWPLTFLSPSELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEH
RRHFPNCPFLENSLETLRFSISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGR
NDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRYPHLLEQLL
STSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQTVQSKILTT
GENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILD
NLLKANVINKQEHDIIKQKTQIPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLF
VDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVVCQECAPSLR
KCPICRGIIKGTVRTFLS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM314219
NameBDBM314219
Synonyms:(S)—N—{(S)-1-[2-Methoxy-6-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-naphthalen-1-ylmethyl]-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl}-2-methylamino-propionamide hydrochloride | US9611224, Example 31
TypeSmall organic molecule
Emp. Form.C28H29N5O5
Mol. Mass.515.5604
SMILESCN[C@@H](C)C(=O)N[C@H]1CCc2ccccc2N(Cc2c(OC)ccc3cc(ccc23)-c2noc(=O)[nH]2)C1=O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a