Target
Baculoviral IAP repeat-containing protein 2
Ligand
BDBM314298
Substrate
n/a
Meas. Tech.
TR-FRET Assay
IC50
85.0±n/a nM
Citation
 Han, XLou, YMichoud, CMischke, SGRemiszewski, SRupert, KC Antiproliferative benzo [B] azepin-2-ones US Patent  US9611224 Publication Date 4/4/2017 
Target
Name:
Baculoviral IAP repeat-containing protein 2
Synonyms:
API1 | BIRC2 | BIRC2_HUMAN | Baculoviral IAP repeat-containing protein 2 (cIAP1) | Cellular inhibitor of apoptosis 1 | Inhibitor of apoptosis protein 2 (cIAP1) | MIHB | RNF48
Type:
Protein
Mol. Mass.:
69900.47
Organism:
Homo sapiens (Human)
Description:
Q13490
Residue:
618
Sequence:
MHKTASQRLFPGPSYQNIKSIMEDSTILSDWTNSNKQKMKYDFSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCSFIQNLVSASLGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRAVEDISSSRTNPYSYAMSTEEARFLTYHMWPLTFLSPSELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLENSLETLRFSISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQTVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQIPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVVCQECAPSLRKCPICRGIIKGTVRTFLS
  
Inhibitor
Name:
BDBM314298
Synonyms:
(S)-2-Methylamino-N-{(S)-2-oxo-1-[2-(2,2,2-trifluoro-ethoxy)-naphthalen-1-ylmethyl]-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl}-propionamide hydrochloride | US9611224, Example 47p
Type:
Small organic molecule
Emp. Form.:
C27H28F3N3O3
Mol. Mass.:
499.5247
SMILES:
CN[C@@H](C)C(=O)N[C@H]1CCc2ccccc2N(Cc2c(OCC(F)(F)F)ccc3ccccc23)C1=O |r|
Structure:
Search PDB for entries with ligand similarity: