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Target
Glycogen synthase kinase-3 beta
Ligand
BDBM314389
Substrate
n/a
Meas. Tech.
In Vitro Assay
IC50
1060±n/a nM
Citation
 Alisi, MA; Cazzolla, N; Dragone, P; Furlotti, G; Maugeri, C; Ombrato, R; Mancini, F 1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors US Patent  US9611249 Publication Date 4/4/2017 
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:
Enzyme
Mol. Mass.:
46756.38
Organism:
Homo sapiens (Human)
Description:
P49841
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
  
Inhibitor
Name:
BDBM314389
Synonyms:
5-(2-ethoxy-4,5-difluorophenyl)-N- {[1-(2-methoxyethyl)piperidin-4- yl]methyl}-1H-indazole-3- carboxamide | US9611249, Compound 18
Type:
Small organic molecule
Emp. Form.:
C25H30F2N4O3
Mol. Mass.:
472.5275
SMILES:
CCOc1cc(F)c(F)cc1-c1ccc2[nH]nc(C(=O)NCC3CCN(CCOC)CC3)c2c1
Structure:
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