Reaction Details Report a problem with these data
Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM314573
Substrate
n/a
Meas. Tech.
Receptor Radioligand Binding Assay
Ki
12.0±n/a nM
Citation
 Coate, HR; Dvorak, CA; Preville, C; Shireman, BT Substituted piperidine compounds and their use as orexin receptor modulators US Patent  US9611251 Publication Date 4/4/2017 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
Hcrtr1 | Hypocretin receptor type 1 | OX1R_RAT | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Ox-1-R | Ox1-R | Ox1R
Type:
Protein
Mol. Mass.:
46817.55
Organism:
Rattus norvegicus (Rat)
Description:
P56718
Residue:
416
Sequence:
MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS
  
Inhibitor
Name:
BDBM314573
Synonyms:
(4-fluoro-2-(pyrimidin-2-yl)phenyl)((2S*,3R*)-2-methyl-3-((5-(trifluoromethyl)pyridin-2-yl)amino)piperidin-1-yl)methanone | US9611251, 191
Type:
Small organic molecule
Emp. Form.:
C23H21F4N5O
Mol. Mass.:
459.4394
SMILES:
C[C@H]1[C@@H](CCCN1C(=O)c1ccc(F)cc1-c1ncccn1)Nc1ccc(cn1)C(F)(F)F |r|
Structure:
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