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Target
Protein O-GlcNAcase
Ligand
BDBM314790
Substrate
n/a
Meas. Tech.
Enzymatic Assay
Ki
726±n/a nM
Citation
 Selnick, HG; Li, W; Hostetler, E; Liu, K; McEachern, EJ; Zhou, Y; Wei, Z; Mu, C; Wang, Y; Chang, J Permeable glycosidase inhibitors and uses thereof US Patent  US9611275 Publication Date 4/4/2017 
Target
Name:
Protein O-GlcNAcase
Synonyms:
2-acetamido-2-deoxy-β-D-glucopyranosidase (O-GlcNAcase) | Beta-N-acetylhexosaminidase | Beta-hexosaminidase (O-GlcNAcase) | Bifunctional protein NCOAT | HEXC | KIAA0679 | MEA5 | MGEA5 | N-acetyl-beta-D-glucosaminidase (O-GlcNAcase) | O-glycoprotein 2-acetamido-2-deoxy-β-D-glucopyranosidase (O-GlcNAcase) | OGA | OGA_HUMAN | Protein O-GlcNAcase
Type:
Enzyme
Mol. Mass.:
102874.67
Organism:
Homo sapiens (Human)
Description:
O60502
Residue:
916
Sequence:
MVQKESQATLEERESELSSNPAASAGASLEPPAAPAPGEDNPAGAGGAAVAGAAGGARRFLCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLMTLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDDIDHNMCAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTEYCGTFCYPNVSQSPYLRTVGEKLLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRSTELIPRLKGVLTNPNCEFEANYVAIHTLATWYKSNMNGVRKDVVMTDSEDSTVSIQIKLENEGSDEDIETDVLYSPQMALKLALTEWLQEFGVPHQYSSRQVAHSGAKASVVDGTPLVAAPSLNATTVVTTVYQEPIMSQGAALSGEPTTLTKEEEKKQPDEEPMDMVVEKQEETDHKNDNQILSEIVEAKMAEELKPMDTDKESIAESKSPEMSMQEDCISDIAPMQTDEQTNKEQFVPGPNEKPLYTAEPVTLEDLQLLADLFYLPYEHGPKGAQMLREFQWLRANSSVVSVNCKGKDSEKIEEWRSRAAKFEEMCGLVMGMFTRLSNCANRTILYDMYSYVWDIKSIMSMVKSFVQWLGCRSHSSAQFLIGDQEPWAFRGGLAGEFQRLLPIDGANDLFFQPPPLTPTSKVYTIRPYFPKDEASVYKICREMYDDGVGLPFQSQPDLIGDKLVGGLLSLSLDYCFVLEDEDGICGYALGTVDVTPFIKKCKISWIPFMQEKYTKPNGDKELSEAEKIMLSFHEEQEVLPETFLANFPSLIKMDIHKKVTDPSVAKSMMACLLSSLKANGSRGAFCEVRPDDKRILEFYSKLGCFEIAKMEGFPKDVVILGRSL
  
Inhibitor
Name:
BDBM314790
Synonyms:
(3aR,5S,6S,7R,7aR)-5-((R)-2- (benzyloxy)-1,1,1-trifluoro-4- phenylbutan-2-yl)-2- (dimethylamino)-5,6,7,7a- tetrahydro-3aH-pyrano[3,2- d]thiazole-6,7-diol | US9611275, Example 76
Type:
Small organic molecule
Emp. Form.:
C25H29F3N2O4S
Mol. Mass.:
510.569
SMILES:
CN(C)C1=N[C@H]2[C@H](O[C@@H]([C@@H](O)[C@@H]2O)[C@@](CCc2ccccc2)(OCc2ccccc2)C(F)(F)F)S1 |t:3|
Structure:
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