Reaction Details Report a problem with these data
Target
Prostaglandin G/H synthase 2
Ligand
BDBM315248
Substrate
n/a
Meas. Tech.
Human PTGES Biochemical Enzyme Inhibition Assay
IC50
20.0±n/a nM
Citation
Bräuer, N; Nagel, J; Irlbacher, H; Rotgeri, A; Schwede, W; Dahllöf, H; Koppitz, M; Peters, M; Godinho-Coelho, A Substituted pyridyl-cycloalkyl-carboxylic acids, compositions containing them and medical uses thereof US Patent US10172814 Publication Date 1/8/2019
More Info.:
Target
Name:
Prostaglandin G/H synthase 2
Synonyms:
COX2 | Cyclooxygenase | Cyclooxygenase 2 (COX-2) | Cyclooxygenase-2 | Cyclooxygenase-2 (COX-2 AA) | Cyclooxygenase-2 (COX-2 AEA) | Cyclooxygenase-2 (COX-2) | PGH synthase 2 | PGH2_HUMAN | PGHS-2 | PHS II | PTGS2 | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin H2 synthase 2 | Prostaglandin-endoperoxide synthase 2
Type:
Enzyme
Mol. Mass.:
69003.89
Organism:
Homo sapiens (Human)
Description:
Recombinant Cox-2 provided by Cayman (Cayman Chemical Co.,Ann Arbor, MI).
Residue:
604
Sequence:
MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFLTRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADYGYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRVAGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEALYGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEVGFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKERSTEL
Inhibitor
Name:
BDBM315248
Synonyms:
(−) 3-[3-({cyclopentyl[3-fluoro-4-(5-isobutyl-6-methylpyridin-3-yl)phenyl]acetyl}amino)-2-methylphenyl]propanoic acid, Single Enantiomer | US10172814, Example 198
Type:
Small organic molecule
Emp. Form.:
C33H39FN2O3
Mol. Mass.:
530.6728
SMILES:
CC(C)Cc1cc(cnc1C)-c1ccc(cc1F)C(C1CCCC1)C(=O)Nc1cccc(CCC(O)=O)c1C