Reaction Details Report a problem with these data
Target
Cathepsin S
Ligand
BDBM315279
Substrate
n/a
Meas. Tech.
Cathepsin Enzyme Inhibition Assay
IC50
2750±n/a nM
Citation
 Haap, W; Kuehne, H; Mauser, H Piperidine derivatives US Patent  US10172843 Publication Date 1/8/2019 
Target
Name:
Cathepsin S
Synonyms:
CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:
Protein
Mol. Mass.:
37507.38
Organism:
Homo sapiens (Human)
Description:
P25774
Residue:
331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
  
Inhibitor
Name:
BDBM315279
Synonyms:
1-[1-[[4-Methyl-2-[4- (trifluoromethyl)phenyl]- 1H-imidazol-5- yl]methyl]-4-piperidyl]- 5H-imidazo[4,5- c]pyridin-4-one | US10172843, Example 13
Type:
Small organic molecule
Emp. Form.:
C23H23F3N6O
Mol. Mass.:
456.4635
SMILES:
Cc1nc([nH]c1CN1CCC(CC1)n1cnc2c1cc[nH]c2=O)-c1ccc(cc1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: