Reaction Details Report a problem with these data
Target
Cathepsin S
Ligand
BDBM315329
Substrate
n/a
Meas. Tech.
Cathepsin Enzyme Inhibition Assay
IC50
667±n/a nM
Citation
 Haap, W; Kuehne, H; Mauser, H Piperidine derivatives US Patent  US10172843 Publication Date 1/8/2019 
Target
Name:
Cathepsin S
Synonyms:
CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:
Protein
Mol. Mass.:
37507.38
Organism:
Homo sapiens (Human)
Description:
P25774
Residue:
331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
  
Inhibitor
Name:
BDBM315329
Synonyms:
3-{1-[5-Methyl-2-(4- trifluoromethyl-phenyl)- 1H-imidazol-4- ylmethyl]-piperidin-4- yl}-1H-pyrrolo[3,2- c]pyridine | US10172843, Example 63
Type:
Small organic molecule
Emp. Form.:
C24H24F3N5
Mol. Mass.:
439.4761
SMILES:
Cc1[nH]c(nc1CN1CCC(CC1)c1c[nH]c2ccncc12)-c1ccc(cc1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: