Reaction Details Report a problem with these data
Target
Eukaryotic initiation factor 4A-III
Ligand
BDBM65492
Substrate
n/a
Meas. Tech.
ATPase enzyme assay
IC50
2.2e+3±n/a nM
Citation
 Iwatani-Yoshihara, M; Ito, M; Ishibashi, Y; Oki, H; Tanaka, T; Morishita, D; Ito, T; Kimura, H; Imaeda, Y; Aparicio, S; Nakanishi, A; Kawamoto, T Discovery and Characterization of a Eukaryotic Initiation Factor 4A-3-Selective Inhibitor That Suppresses Nonsense-Mediated mRNA Decay. ACS Chem Biol 12:1760-1768 (2017) [PubMed]  Article 
Target
Name:
Eukaryotic initiation factor 4A-III
Synonyms:
ATP-dependent RNA helicase DDX48 | ATP-dependent RNA helicase eIF4A-3 | DDX48 | DEAD box protein 48 | EIF4A3 | Eukaryotic initiation factor 4A-like NUK-34 | Eukaryotic translation initiation factor 4A isoform 3 | IF4A3_HUMAN | KIAA0111 | NMP 265 | Nuclear matrix protein 265 | eIF-4A-III | eIF4A-III | hNMP 265
Type:
Protein
Mol. Mass.:
46871.02
Organism:
Homo sapiens (Human)
Description:
P38919
Residue:
411
Sequence:
MATTATMATSGSARKRLLKEEDMTKVEFETSEEVDVTPTFDTMGLREDLLRGIYAYGFEKPSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILAPTRELAVQIQKGLLALGDYMNVQCHACIGGTNVGEDIRKLDYGQHVVAGTPGRVFDMIRRRSLRTRAIKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLISATLPHEILEMTNKFMTDPIRILVKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLTEKMREANFTVSSMHGDMPQKERESIMKEFRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNRELYIHRIGRSGRYGRKGVAINFVKNDDIRILRDIEQYYSTQIDEMPMNVADLI
  
Inhibitor
Name:
BDBM65492
Synonyms:
eIF4A3 inhibitor, 1
Type:
Small organic molecule
Emp. Form.:
C27H21Cl2N3O3
Mol. Mass.:
506.38
SMILES:
Clc1ccc(cc1)C1CN(CCN1C(=O)c1ccc(Cl)cc1)C(=O)c1cnc(o1)-c1ccccc1
Structure:
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