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Target
Histamine H4 receptor
Ligand
BDBM315365
Substrate
n/a
Meas. Tech.
Binding Assay on Recombinant Human Histamine H4 Receptor
Ki
62.0±n/a nM
Citation
 Bacani, GM; Chai, W; Edwards, JP; Smith, RC; Tichenor, MS; Venable, JD; Wei, J 2,4-diaminopyrimidine derivatives as histamine H4 modulators US Patent  US10172856 Publication Date 1/8/2019 
Target
Name:
Histamine H4 receptor
Synonyms:
AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44517.02
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:
390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
  
Inhibitor
Name:
BDBM315365
Synonyms:
US10172856, Example 18
Type:
Small organic molecule
Emp. Form.:
C16H14F4N6O
Mol. Mass.:
382.3156
SMILES:
Nc1nccc(n1)N(Cc1cc[nH]n1)c1ccc(F)cc1OCC(F)(F)F
Structure:
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