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TargetIDH1 R132H
LigandBDBM280053
Substrate/Competitorn/a
Meas. Tech.In Vitro Assays for IDH1m (R132H or R132C) Inhibitors
IC50<50±n/a nM
Citation Konteatis, ZDPopovici-Muller, JTravins, JMZahler, RCai, ZZhou, D Therapeutically active compounds and their methods of use US Patent US10172864 Publication Date 1/8/2019
More Info.:Get all data from this article,  Assay Method
 
IDH1 R132H
Name:IDH1 R132H
Synonyms:Amyloid-beta 1-40 | IDH1(R132H) | Isocitrate dehydrogenase (IDH1)(R132H) | Isocitrate dehydrogenase 1 mutant (R132H) | Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)(R132H) | Isocitrate dehydrogenase [NADP] cytoplasmic (R132H)
Type:Enzyme Catalytic Domain
Mol. Mass.:46641.74
Organism:Homo sapiens (human)
Description:n/a
Residue:414
Sequence:
MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA
AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL
VSGWVKPIIIGHHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM
GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE
AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG
KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE
EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
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  Blast E-value cutoff:
BDBM280053
NameBDBM280053
Synonyms:US10028961, Compound 206 | US10172864, Compound 206
TypeSmall organic molecule
Emp. Form.C23H25F3N6
Mol. Mass.442.48
SMILESCC(Cc1ccccc1)Nc1nc(N[C@H](C)C2CC2)nc(n1)-c1cccc(n1)C(F)(F)F |r|
Structure
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n/a