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Target
Beta-glucuronidase
Ligand
BDBM316402
Substrate
n/a
Meas. Tech.
β-Glucuronidase Activity Assay
IC50
600±n/a nM
Citation
 Williams, AL; Scott, J; Yeh, L; Redinbo, MR Phenoxy thiophene sulfonamides and their use as inhibitors of glucuronidase US Patent  US9617239 Publication Date 4/11/2017 
Target
Name:
Beta-glucuronidase
Synonyms:
β-Glucuronidase | BGLR_HUMAN | Beta-G1 | Beta-glucuronidase | GUSB | beta-Glucuronidase (β-glucuronidase)
Type:
Protein
Mol. Mass.:
74736.05
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
651
Sequence:
MARGSAVAWAALGPLLWGCALGLQGGMLYPQESPSRECKELDGLWSFRADFSDNRRRGFEEQWYRRPLWESGPTVDMPVPSSFNDISQDWRLRHFVGWVWYEREVILPERWTQDLRTRVVLRIGSAHSYAIVWVNGVDTLEHEGGYLPFEADISNLVQVGPLPSRLRITIAINNTLTPTTLPPGTIQYLTDTSKYPKGYFVQNTYFDFFNYAGLQRSVLLYTTPTTYIDDITVTTSVEQDSGLVNYQISVKGSNLFKLEVRLLDAENKVVANGTGTQGQLKVPGVSLWWPYLMHERPAYLYSLEVQLTAQTSLGPVSDFYTLPVGIRTVAVTKSQFLINGKPFYFHGVNKHEDADIRGKGFDWPLLVKDFNLLRWLGANAFRTSHYPYAEEVMQMCDRYGIVVIDECPGVGLALPQFFNNVSLHHHMQVMEEVVRRDKNHPAVVMWSVANEPASHLESAGYYLKMVIAHTKSLDPSRPVTFVSNSNYAADKGAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSEYGAETIAGFHQDPPLMFTEEYQKSLLEQYHLGLDQKRRKYVVGELIWNFADFMTEQSPTRVLGNKKGIFTRQRQPKSAAFLLRERYWKIANETRYPHSVAKSQCLENSLFT
  
Inhibitor
Name:
BDBM316402
Synonyms:
US9617239, BRITE-355014
Type:
Small organic molecule
Emp. Form.:
C19H21N3O3S3
Mol. Mass.:
435.583
SMILES:
O=S(=O)(NCc1cccs1)c1ccc(Oc2cccc(c2)N2CCNCC2)s1
Structure:
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