Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM316500
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
75.4±n/a nM
Citation
 Kuduk, SD; Skudlarek, JW Thioether-piperidinyl orexin receptor antagonists US Patent  US9617246 Publication Date 4/11/2017 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM316500
Synonyms:
2-{[(3R,6R)-6-methyl-1-{[2- (methylsulfanyl)phenyl]carbonyl} piperidin-3-yl]sulfanyl}pyridine-4- carbonitrile | US9617246, 34
Type:
Small organic molecule
Emp. Form.:
C20H21N3OS2
Mol. Mass.:
383.53
SMILES:
CSc1ccccc1C(=O)N1C[C@@H](CC[C@H]1C)Sc1cc(ccn1)C#N
Structure:
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