Target
cGMP-dependent protein kinase 1
Ligand
BDBM10841
Substrate
Histone H1
Meas. Tech.
Kinase Inhibition Assay
Temperature
303.15±n/a K
IC50
800±n/a nM
Comments
extracted
Citation
 Gompel, MLeost, MDe Kier Joffe, EBPuricelli, LFranco, LHPalermo, JMeijer, L Meridianins, a new family of protein kinase inhibitors isolated from the ascidian Aplidium meridianum. Bioorg Med Chem Lett 14:1703-7 (2004) [PubMed]  Article 
Target
Name:
cGMP-dependent protein kinase 1
Synonyms:
CGK 1 alpha | KGP1_BOVIN | PRKG1 | PRKG1B | PRKGR1A | PRKGR1B | cGMP-Dependent Protein Kinase | cGMP-dependent protein kinase 1 alpha | cGMP-dependent protein kinase 1, alpha isozyme
Type:
Enzyme
Mol. Mass.:
76413.14
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
671
Sequence:
MSELEEDFAKILMLKEERIKELEKRLSEKEEEIQELKRKLHKCQSVLPVPSTHIGPRTTRAQGISAEPQTYRSFHDLRQAFRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGKVNVTREDSPNEDPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPPPDDNSGWDIDF
  
Inhibitor
Name:
BDBM10841
Synonyms:
4-(6-bromo-1H-indol-3-yl)pyrimidin-2-amine | Meridianin D
Type:
Small organic molecule
Emp. Form.:
C12H9BrN4
Mol. Mass.:
289.131
SMILES:
Nc1nccc(n1)-c1c[nH]c2cc(Br)ccc12
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Histone H1
Synonyms:
n/a
Type:
Other Protein Type
Mol. Mass.:
358.43
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
3
Sequence:
NA