Reaction Details Report a problem with these data
Target
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI
Ligand
BDBM316918
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
4800±n/a nM
Citation
 Guillemont, JE; Lancois, DF; Motte, MM; Koul, A; Balemans, WM; Arnoult, EP Antibacterial cyclopental[C]pyrrole substituted 3,4-dihydro-1H-[1,8]naphthyridinones US Patent  US9617262 Publication Date 4/11/2017 
Target
Name:
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI
Synonyms:
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI | Enoyl-acyl carrier protein reductase (FaBI) | FABI_STAA8 | NADPH-dependent enoyl-ACP reductase (FabI) | fabI
Type:
Enzyme
Mol. Mass.:
28019.03
Organism:
Staphylococcus aureus
Description:
Q2FZQ3
Residue:
256
Sequence:
MLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISASPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK
  
Inhibitor
Name:
BDBM316918
Synonyms:
US9617262, Compound 34
Type:
Small organic molecule
Emp. Form.:
C18H19F2N3O2
Mol. Mass.:
347.3592
SMILES:
FC1(F)CC2CN(CC2C1)C(=O)\C=C\c1cnc2NC(=O)CCc2c1
Structure:
Search PDB for entries with ligand similarity: