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TargetbRAF serine/threonine protein kinase
LigandBDBM316965
Substrate/Competitorn/a
Meas. Tech.Biochemical Assay
IC50>100.0±n/a nM
Citation Ibrahim, PNSpevak, WCho, HShi, SZhang, CZhang, Y Compounds and methods for kinase modulation, and indications therefor US Patent US9617267 Publication Date 4/11/2017  Article
More Info.:Get all data from this article,  Assay Method
 
bRAF serine/threonine protein kinase
Name:RAF serine/threonine protein kinase
Synonyms:B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | Serine/threonine-protein kinase B-raf
Type:Serine/threonine-protein kinase
Mol. Mass.:84446.00
Organism:Homo sapiens (Human)
Description:n/a
Residue:766
Sequence:
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM316965
NameBDBM316965
Synonyms:N-[3-(4-Chloro-7H- pyrrolo[2,3-d]pyrimidine-5- carbonyl)-2,4-difluoro- phenyl]-4-trifluoromethyl- benzenesulfonamide | US9617267, Compound P-1016
TypeSmall organic molecule
Emp. Form.C20H10ClF5N4O3S
Mol. Mass.516.828
SMILESFc1ccc(NS(=O)(=O)c2ccc(cc2)C(F)(F)F)c(F)c1C(=O)c1c[nH]c2ncnc(Cl)c12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a