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TargetbRAF serine/threonine protein kinase
LigandBDBM316979
Substrate/Competitorn/a
Meas. Tech.Biochemical Assay
IC50>100.0±n/a nM
Citation Ibrahim, PNSpevak, WCho, HShi, SZhang, CZhang, Y Compounds and methods for kinase modulation, and indications therefor US Patent US9617267 Publication Date 4/11/2017
More Info.:Get all data from this article,  Assay Method
 
bRAF serine/threonine protein kinase
Name:RAF serine/threonine protein kinase
Synonyms:B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | Serine/threonine-protein kinase B-raf
Type:Serine/threonine-protein kinase
Mol. Mass.:84446.00
Organism:Homo sapiens (Human)
Description:n/a
Residue:766
Sequence:
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM316979
NameBDBM316979
Synonyms:N-[2,4-Difluoro-3-(4- hydroxy-7H-pyrrolo[2,3- d]pyrimidine-5-carbonyl)- phenyl]-4-propyl- benzenesulfonamide | US9617267, Compound P-1030
TypeSmall organic molecule
Emp. Form.C22H18F2N4O4S
Mol. Mass.472.465
SMILESCCCc1ccc(cc1)S(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncnc(O)c23)c1F
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a