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Target
Amine oxidase [flavin-containing] A
Ligand
BDBM10998
Substrate
BDBM10990
Meas. Tech.
MAO A and MAO B Activity Measurements
pH
7.5±n/a
Temperature
298.15±n/a K
Ki
160000±n/a nM
Citation
 Binda, C; Hubalek, F; Li, M; Herzig, Y; Sterling, J; Edmondson, DE; Mattevi, A Binding of rasagiline-related inhibitors to human monoamine oxidases: a kinetic and crystallographic analysis. J Med Chem 48:8148-54 (2005) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] A
Synonyms:
AOFA_HUMAN | Amine oxidase (flavin-containing) A | MAO-A | MAOA | Monoamine oxidase | Monoamine oxidase type A | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAOA)
Type:
Protein
Mol. Mass.:
59689.53
Organism:
Homo sapiens (Human)
Description:
P21397
Residue:
527
Sequence:
MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
  
Inhibitor
Name:
BDBM10998
Synonyms:
(1S)-2,3-dihydro-1H-inden-1-amine | 1(S)-aminoindan | S-AI | rasagiline analog
Type:
Small organic molecule
Emp. Form.:
C9H11N
Mol. Mass.:
133.1903
SMILES:
N[C@H]1CCc2ccccc12 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM10990
Synonyms:
3-amino-1-(2-aminophenyl)propan-1-one | Diaminopropiophenone | Kynuramine
Type:
Small organic molecule
Emp. Form.:
C9H12N2O
Mol. Mass.:
164.2044
SMILES:
NCCC(=O)c1ccccc1N
Structure:
Search PDB for entries with ligand similarity: