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Target
Amine oxidase [flavin-containing] B
Ligand
BDBM10992
Substrate
BDBM10999
Meas. Tech.
MAO A and MAO B Activity Measurements
pH
7.5±n/a
Temperature
298.15±n/a K
Ki
130000±n/a nM
Citation
 Binda, C; Hubalek, F; Li, M; Herzig, Y; Sterling, J; Edmondson, DE; Mattevi, A Binding of rasagiline-related inhibitors to human monoamine oxidases: a kinetic and crystallographic analysis. J Med Chem 48:8148-54 (2005) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB)
Type:
Protein
Mol. Mass.:
58768.76
Organism:
Homo sapiens (Human)
Description:
P27338
Residue:
520
Sequence:
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
  
Inhibitor
Name:
BDBM10992
Synonyms:
rasagiline analog | (1R)-1-[methyl(prop-2-yn-1-yl)amino]-2,3-dihydro-1H-inden-4-yl N-ethyl-N-methylcarbamate | 4-(N-methyl-N-ethyl-carbamoyloxy)-N-methyl-N-propargyl-1(R)-aminoindan | R-M4CPAI
Type:
Small organic molecule
Emp. Form.:
C17H22N2O2
Mol. Mass.:
286.3688
SMILES:
CCN(C)C(=O)Oc1cccc2[C@@H](CCc12)N(C)CC#C |r|
Structure:
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Substrate
Name:
BDBM10999
Synonyms:
Benzenemethanamine | Bn-NH2 | CHEMBL522 | benzylamine | phenylmethanamine
Type:
Small organic molecule
Emp. Form.:
C7H9N
Mol. Mass.:
107.1531
SMILES:
NCc1ccccc1
Structure:
Search PDB for entries with ligand similarity: