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TargetMonoamine Oxidase Type A (MAO-A)
LigandBDBM11014
Substrate/CompetitorBDBM10990
Meas. Tech.MAO Inhibition Assay
pH7.4±n/a
Temperature311.15±n/a K
Ki 50±0.2 nM
Citation Chimenti, FMaccioni, ESecci, DBolasco, AChimenti, PGranese, ABefani, OTurini, PAlcaro, SOrtuso, FCirilli, RLa Torre, FCardia, MCDistinto, S Synthesis, molecular modeling studies, and selective inhibitory activity against monoamine oxidase of 1-thiocarbamoyl-3,5-diaryl-4,5-dihydro-(1H)- pyrazole derivatives. J Med Chem48:7113-22 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Monoamine Oxidase Type A (MAO-A)
Name:Monoamine oxidase
Synonyms:Amine oxidase [flavin-containing] A | MAO-A | Monoamine oxidase A | Monoamine oxidase type A
Type:PROTEIN
Mol. Mass.:59764.63
Organism:Bos taurus
Description:ChEMBL_1501477
Residue:527
Sequence:
MESLQKTSDAGQMFDVVVIGGGISGLSAAKLLAEHEVNVLVLEARERVGGRTYTVRNEHV
DYVDVGGAYVGPTQNRILRLSKQLGLETYKVNVNERLVHYVKGKTYPFRGAFPPVWNPIA
YLDYNNLWRTMDNMGKEIPADAPWEAPHAVEWDKMTMKDLIEKICWTKTARQFASLFVNI
NVTSEPHEVSALWFLWYVKQCGGTTRIFSITNGGQERKFVGGSGQVSERIMQLLGDRVKL
RSPVTYVDQSSENITVETLNRELYECRYVISAIPPTLTAKIHFRPELPSERNQLIQRLPM
GAVIKCMMYYKEAFWKKKDYCGCMIIEDEEAPISITLDDTKPDGSLPAIMGFILARKADR
LAKVHKDIRKRKICELYAKVLGSQEALHPVHYEEKNWCQEQYSGGCYTAYFPPGIMTQYG
RVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKLSAKDIWIQEPEAED
VPAVEITPSFWERNLPSVSGLLKIVGFSTSITALWFVMYRFRLLSRS
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BDBM11014
NameBDBM11014
Synonyms:(-)-(S)1 | (5S)-5-(4-chlorophenyl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide | 1-thiocarbamoyl-3,5-diaryl-4,5-dihydro-(1H)-pyrazole deriv. 1S
TypeSmall organic molecule
Emp. Form.C17H16ClN3S
Mol. Mass.329.847
SMILESCc1ccc(cc1)C1=NN([C@@H](C1)c1ccc(Cl)cc1)C(N)=S |r,t:8|
Structure
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BDBM10990
NameBDBM10990
Synonyms:3-amino-1-(2-aminophenyl)propan-1-one | Diaminopropiophenone | Kynuramine
TypeSmall organic molecule
Emp. Form.C9H12N2O
Mol. Mass.164.2044
SMILESNCCC(=O)c1ccccc1N
Structure
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