Reaction Details Report a problem with these data
Target
Alpha-1A adrenergic receptor
Ligand
BDBM317610
Substrate
n/a
Meas. Tech.
Binding Assay
IC50
41.0±n/a nM
Citation
Becker-Pelster, EM; Buchgraber, P; Buchmüller, A; Engel, K; Göller, A; Himmel, H; Kast, R; Keldenich, J; Schmeck, C; Tinel, H; Wunder, F Substituted bipiperidinyl derivatives US Patent US9624199 Publication Date 4/18/2017
More Info.:
Target
Name:
Alpha-1A adrenergic receptor
Synonyms:
ADA1A_HUMAN | ADRA1A | ADRA1C | Adrenergic alpha1A | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha adrenergic receptor 1a | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1 | adrenergic Alpha1C
Type:
Cell-surface receptors
Mol. Mass.:
51511.67
Organism:
Homo sapiens (Human)
Description:
P35348
Residue:
466
Sequence:
MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCTTARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
Inhibitor
Name:
BDBM317610
Synonyms:
US9624199, 20 | {2-[(2R)-2-(Methoxymethyl)pyrrolidin-1-yl]pyrimidin-5-yl}[(3R)-3-methyl-1,4′-bipiperidin-1′-yl]methanone
Type:
Small organic molecule
Emp. Form.:
C22H35N5O2
Mol. Mass.:
401.5456
SMILES:
COC[C@H]1CCCN1c1ncc(cn1)C(=O)N1CCC(CC1)N1CCC[C@@H](C)C1 |r|