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Target
Bromodomain-containing protein 4 [342-460]
Ligand
BDBM318458
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
<100±n/a nM
Citation
 Combs, AP; Sparks, RB; Maduskuie, Jr., TP Tricyclic heterocycles as BET protein inhibitors US Patent  US9624241 Publication Date 4/18/2017 
Target
Name:
Bromodomain-containing protein 4 [342-460]
Synonyms:
BRD4 | BRD4-BD2 (aa 342-460) | BRD4_HUMAN | Bromodomain containing 4 (aa 342-460) | Bromodomain-containing protein 4 (BRD4)(BD2) | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13783.81
Organism:
Homo sapiens (Human)
Description:
a.a. 342-460 (BRD4-BD2)
Residue:
119
Sequence:
PAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDE
  
Inhibitor
Name:
BDBM318458
Synonyms:
7-(3,5-Dimethylisoxazol-4-yl)-5-methyl-4-phenyl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2(1H)-one | US10464947, Example 3 | US11498926, Example 3 | US9624241, Example 3
Type:
Small organic molecule
Emp. Form.:
C21H19N3O3
Mol. Mass.:
361.3939
SMILES:
CC1Oc2c(ccc3[nH]c(=O)n(C1c1ccccc1)c23)-c1c(C)noc1C |(-2.82,1.54,;-1.48,.77,;-1.48,-.77,;-.15,-1.54,;-.15,-3.08,;1.18,-3.85,;2.52,-3.08,;2.52,-1.54,;3.85,-.77,;2.72,.77,;3.49,2.1,;1.18,.77,;-.15,1.54,;-.15,3.08,;1.18,3.85,;1.18,5.39,;-.15,6.16,;-1.48,5.39,;-1.48,3.85,;1.18,-.77,;-1.48,-3.85,;-2.95,-3.37,;-3.72,-2.04,;-3.85,-4.62,;-2.95,-5.87,;-1.48,-5.39,;-.15,-6.16,)|
Structure:
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